| Di., 14.02. | Rubin Kazan | - | Olympiakos Piräus | 18.00 | ||||
| Sporting Braga | - | Besiktas Istanbul | 18.30 | |||||
| Do., 16.02. | Lokomotive Moskau | - | Athletic Bilbao | 18.00 | ||||
| AZ Alkmaar | - | Anderlecht | 19.00 | |||||
| Red Bull Salzburg | - | Metalist Kharkow | 19.00 | |||||
| Ajax Amsterdam | - | Manchester United | 19.00 | |||||
| Viktoria Pilsen | - | FC Schalke 04 | 19.00 | |||||
| Legia Warschau | - | Sporting Lissabon | 19.00 | |||||
| Lazio Rom | - | Atlético Madrid | 19.00 | |||||
| Stoke City | - | FC Valencia | 21.05 | |||||
| FC Porto | - | Manchester City | 21.05 | |||||
| Hannover 96 | - | FC Brügge | 21.05 | |||||
| Trabzonspor | - | PSV Eindhoven | 21.05 | |||||
| Udinese | - | PAOK Saloniki | 21.05 | |||||
| Wisla Krakau | - | Standard Lüttich | 21.05 | |||||
| Steaua Bukarest | - | Twente Enschede | 21.05 | |||||
| Mi., 22.02. | Manchester City | - | FC Porto | 18.00 | ||||
| Do., 23.02. | FC Brügge | - | Hannover 96 | 19.00 | ||||
| Twente Enschede | - | Steaua Bukarest | 19.00 | |||||
| FC Valencia | - | Stoke City | 19.00 | |||||
| Athletic Bilbao | - | Lokomotive Moskau | 19.00 | |||||
| PAOK Saloniki | - | Udinese | 19.00 | |||||
| Standard Lüttich | - | Wisla Krakau | 19.00 | |||||
| PSV Eindhoven | - | Trabzonspor | 19.00 | |||||
| Olympiakos Piräus | - | Rubin Kazan | 21.05 | |||||
| Metalist Kharkow | - | Red Bull Salzburg | 21.05 | |||||
| Besiktas Istanbul | - | Sporting Braga | 21.05 | |||||
| Sporting Lissabon | - | Legia Warschau | 21.05 | |||||
| Anderlecht | - | AZ Alkmaar | 21.05 | |||||
| Atlético Madrid | - | Lazio Rom | 21.05 | |||||
| FC Schalke 04 | - | Viktoria Pilsen | 21.05 | |||||
| Manchester United | - | Ajax Amsterdam | 21.05 | |||||